UCSD NASA Lab - People - Cortney Henderson

	Cortney Henderson, Ph.D.
	Post-Doctoral Fellow UCSD Department of Medicine 9500 Gilman Dr., 0931 La Jolla, CA 92093-0931 Email:

Education
Mercer University, Macon, GA	B.S.E. (Hons)	1990	Majors: Biomedical Engineering and Mathematics
Boston University, Boston, MA	Ph.D.	2002	Biomedical Engineering

	Research & Professional Experience
	1997	Graduate Teaching Fellow, Department of Biomedical Engineering, Boston University, Boston, MA
	1998-99	Graduate Research Fellow, Department of Biomedical Engineering, Boston University, Boston, MA
	1999-2002	Ph.D. Candidate, Department of Biomedical Engineering, Boston University, Boston, MA
	2002-03	Assistant Language Teacher, Japan Exchange and Teaching (JET) Program, Yokohama, JAPAN
	2004-	Postgraduate Research Physiologist, Division of Physiology, Department of Medicine, University of California, San Diego

	Research Focus
	My research focuses on performing noninvasive measurements in humans, using established techniques and novel functional magnetic resonance imaging (MRI) techniques, to study lung physiology in health and disease.
	Head-down Tilt and Graded Saline Infusion Thus far we have used such techniques to elucidate changes in the heterogeneity of lung mechanics, pulmonary blood flow, and lung density that occur during the early stages of pulmonary interstitial edema. We utilize either 30-degree head-down tilt or graded saline infusion to provoke an increase in fluid content of the lung, and consequently the early stages of pulmonary interstitial edema. Our study has relevance for providing (1) a basic understanding of how the early stages of pulmonary interstitial edema affects lung function, and (2) models that can be used for studies related to the diagnosis and treatment of subclinical edema.
	The Effects of Gravity on the Lung The lung is strongly influenced by gravity; therefore studying lung physiology in the absence of gravity has been of great interest for our lab for many years. The NASA Lab has been directly involved in almost all of the studies of lung function performed in space since the Shuttle began flying. These have included studies on SLS-1 (STS-40), SLS-2 (STS-58), LMS (STS-78), Neurolab (STS-90), D-2 (STS-55), ST-95 and STS-107. My work in this area has primarily involved ground studies using novel MRI techniques to study the effects of gravity on the lung.
	Chronic Obstructive Pulmonary Disease (COPD) We are now in a position to utilize the sophisticated MRI techniques we have developed to quantify the spatial pattern of density, blood flow, and ventilation in the human lung in vivo. Use of these MRI techniques, combined with the multiple inert gas elimination technique (MIGET) and computed tomography (CT) imaging, could provide insight into how the different phenotypes of COPD are mechanistically different. A better understanding of the underlying physiology in the different phenotypes of COPD may allow for the identification of patients that would most benefit from current therapies, as well as provide pathways for future therapies.

	Positions and Honors
	Positions
	1997	Graduate Teaching Fellow, Dept of Biomedical Engineering, Boston University
	1998-1999	Graduate Research Fellow, Dept of Biomedical Engineering, Boston University
	1999-2002	PhD Candidate, Dept of Biomedical Engineering, Boston University
	2004-2005	Postgraduate Researcher, NASA Lab, Dept of Medicine, University of California, San Diego
	2005-	Postdoctoral Scholar-Fellow, NASA Lab, Dept of Medicine, University of California, San Diego
	Honors and Awards
	1997	Outstanding Graduate in Biomedical Engineering Award, Mercer University
	1998	Outstanding Graduate Teaching Fellow Award, Boston University
	2004-2006	National Institute of Health, Clinical Research Loan Repayment Program Award
	2005-2008	National Institute of Health, Ruth L. Kirschstein National Research Service Award for Postdoctoral Fellows
	2005-2006	American Association of University Women Postdoctoral Fellowship (Declined)
	2006	“Transforming the Professoriate: Preparing Women for Academic Careers in Science and Engineering”, Professional Development Workshop sponsored by National Science Foundation, Virginia Tech (20% acceptance rate)
	2006-2008	National Institute of Health, Clinical Research Loan Repayment Program Award Renewal

Publications

Manuscripts
1.	Sharma R, Henderson C, Warren GW, and Burkett SL. Study of electrical properties of polymeric materials using electrochemical impedance spectroscopy. J Appl Polym Sci 68(4): 553-560, 1998.
2.	Gray RI, Ott DE, Henderson AC, Cochran SA, and Roth EA. Severe local hypothermia from laparoscopic gas evaporative jet cooling: a mechanism to explain clinical observations. JSLS 3(3): 171-7, 1999.
3.	Ingenito EP, Berger RL, Henderson AC, Reilly JJ, Tsai L, and Hoffman A. Bronchoscopic lung volume reduction using tissue engineering principles. Am J Respir Crit Care Med 167(5): 771-8, 2003.
4.	Hoffman A, Henderson AC, Tsai L, and Ingenito E. Physiologic responses of sheep to two different methods of papain exposure. Inhal Toxicol 15(8): 761-80, 2003.
5.	Henderson AC, Ingenito EP, Atileh H, Israel E, Suki B, and Lutchen KR. How does airway inflammation modulate asthmatic airway constriction? An antigen challenge study. J Appl Physiol 95(2): 873-82, 2003; discussion p. 863 (featured as a Selected Contribution in the "Airway Hyperresponsiveness: From Molecules to Bedside" Highlighted Topics series).
6.	Black LD, Henderson AC, Atileh H, Israel E, Ingenito EP, and Lutchen KR. Relating maximum airway dilation and subsequent reconstriction to reactivity in human lungs. J Appl Physiol 96(5):1808-14, 2004.
7.	Henderson AC, Levin DL, Hopkins SR, Olfert IM, and RB Buxton. Steep head-down tilt has persisting effects on the distribution of pulmonary blood flow. J Appl Physiol 101(2): 583-9, 2006.
8.	Henderson AC, Ingenito EP, Loring SH, Moy ML, Reilly JJ, Salcedo ES, Suki B, and Lutchen KR. Dynamic lung mechanics in late-stage emphysema before and after lung volume reduction surgery. J Appl Physiol (In preparation).
9.	Hopkins SR, Henderson AC, Levin DL, Yamada K, Arai T, Buxton RB, and GK Prisk. Vertical gradients in regional lung density and perfusion in the human lung: the Slinky® effect. J Appl Physiol 103(1):240-8, 2007. Epub March 2007.
10.	Prisk GK, Yamada K, Henderson AC, Arai T, Levin D, Buxton RB, and SR Hopkins. Pulmonary perfusion in the prone and supine postures in the normal human lung. J Appl Physiol 103(3):883-94, 2007. Epub June 2007.
11.	Henderson AC, Prisk GK, Levin DL, Hopkins SR, and RB Buxton. Characterizing pulmonary blood flow distribution measured using arterial spin labeling. Magn Reson Med [Submitted 3/2008].
12.	Henderson AC, Arai TJ, Levin DL, Buxton RB, Prisk GK, and SR Hopkins. Regional pulmonary blood flow is affected by lung volume. J Appl Physiol [In Preparation].
13.	Henderson AC, Dubowitz DJ, Levin DL, Friedman PJ, Buxton RB, Prisk GK, and SR Hopkins. Hypoxic pulmonary vasoconstriction does not contribute to pulmonary blood flow heterogeneity in normoxia in normal humans. J Appl Physiol [In Preparation].
Abstracts and Proceedings
1.	Gray RI, Henderson AC, Cochran SA, and DE Ott. Severe hypothermia from laparoscopic gas evaporative jet cooling: a possible mechanism to explain widespread clinical observations. Ann Biomed Eng 25, Supplement 1, S-28, 1997.
2.	Jensen A, Suki B, Atileh H, Henderson C, Ingenito E, Israel E, and K Lutchen. Tracking changes in airway caliber for healthy and asthmatic patients during tidal breathing and deep inspirations before and after a bronchial challenge. Am J Respir Crit Care Med 161(3): A281, 2000.
3.	Henderson C, Salcedo E, Ingenito E, Loring S, Moy M, Atileh H, and KR Lutchen. Probing dynamic lung mechanical properties in emphysema patients. Ann Biomed Eng 28, Supplement 1, S-48, 2000.
4.	Henderson AC, Ingenito EP, Hoffman A, and KR Lutchen. Probing the effects of lung volume reduction and induced emphysema on dynamic lung mechanics in sheep. Am J Respir Crit Care Med 163(5): A824, 2001.
5.	Ingenito EP, Tsai L, Gilmartin G, Reilly JJ, Henderson C, Keuhn H, and A Hoffman. Bronchoscopic volume reduction (BVR) using biopolymers which target fibroblast, macrophage, and epithelial cell responses. Am J Respir Crit Care Med 163(5): A957, 2001.
6.	Jensen A, Henderson C, Atileh H, Ingenito E, and KR Lutchen. In vivo airway smooth muscle dynamics during a deep inspiration (DI) in asthmatics versus healthy subjects. Am J Respir Crit Care Med 163(5): A832, 2001.
7.	Black LD, Henderson C, Atileh H, Ingenito EP, and KR Lutchen. Dependence of maximum airway dilation capacity in asthmatics on rate of deep-inspiration maneuver. Ann Biomed Eng 29, Supplement 1, S-135, 2001.
8.	Henderson C, Atileh H, Ingenito EP, Suki B, and KR Lutchen. Probing dynamic lung mechanical properties in asthmatics before and after an antigen challenge. Ann Biomed Eng 29, Supplement 1, S-144, 2001.
9.	Henderson AC, Atileh H, Ingenito EP, and KR Lutchen. Airway constriction and dilation capacity in asthmatics before and after an antigen challenge. Am J Respir Crit Care Med 165(8): A778, 2002.
10.	Henderson AC, Ingenito EP, Hoffman A, and KR Lutchen. Work of breathing (WOB) in emphysema pre- and post- lung volume reduction. Am J Respir Crit Care Med 165(8): A586, 2002.
11.	Hoffman AM, Kuehn H, Henderson AC, Reilly J, Miskovic MB, McCool J, and EP Ingenito. Ovine papain induced emphysema: lung-chest wall physiology. Am J Respir Crit Care Med 165(8): A152, 2002.
12.	Ingenito EP, Berger R, Henderson AC, Tsai L, Reilly JJ, Moy M, McCool J, Kuehn H, Miscovic M, Kinney L, and A Hoffman. CT-guided bronchoscopic volume reduction (BVR) therapy for emphysema. Am J Respir Crit Care Med 165(8): A144, 2002.
13.	Henderson AC, Olfert IM, Hopkins SR, Levin DL, and GK Prisk. Effects of 30-degree head-down tilt on the distribution of pulmonary blood flow. Proceedings of the American Thoracic Society 2:A582, 2005.
14.	Levin DL, Speiss J, Henderson AC, Bedell M, and SR Hopkins. Functional magnetic resonance imaging of pulmonary blood flow in smokers, patients with COPD, and normal subjects. Proceedings of the American Thoracic Society 2:A332, 2005.
15.	Henderson AC, Hopkins SR, Levin DL, Buxton RB, and GK Prisk. Alterations in peripheral pulmonary blood flow distribution before and after 30-degree head-down tilt. Proceedings of the American Thoracic Society 3:A62, 2006.
16.	Prisk GK, Yamada K, Levin DL, Henderson AC, Arai T, Buxton RB, and SR Hopkins. Vertical distribution of pulmonary perfusion and lung density in humans: The Slinky® effect. Eur. Respir. J 28: Supplement 50, P2389.
17.	Arai T, Dubowitz DJ, Henderson AC, Levin DL, Friedman PJ, Buxton RB, Prisk GK, and SR Hopkins. Spatial heterogeneity of pulmonary perfusion in normoxia is not due to hypoxic pulmonary vasoconstriction. High Alt Med Biol 7(4):320, 2006.
18.	Hopkins SR, Levin DL, Arai T, Henderson AC, Buxton RB, and GK Prisk. Does lung compression reduce perfusion in the supine posture? Am J Respir Crit Care Med 175:A817, 2007.
19.	Burnham KJ, Arai T, Dubowitz DJ, Henderson AC, Buxton RB, Prisk GK, and SR Hopkins. The Effect of Sustained, Heavy Exercise on Pulmonary Perfusion Heterogeneity. Am J Respir Crit Care Med 177: A223, 2008.